Effect of Aqueous Extract of Salacia Reticulata on Aluminum Chloride Induced Cellular Changes on Cerebral Cortex of Wistar Rats
Elvis Tams Godman 1, Okwute Michael Ochayi 2 *
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1 Department of Human Anatomy, Faculty of Medicine, Bingham University, Karu, Nigeria
2 Department of Human Physiology, Faculty of Basic Medical Sciences, Baze University, Abuja, Nigeria
* Corresponding Author

Abstract

Background: Aluminum chloride is a potent neurotoxic compound that is being implicated in several neuropathological disorders. Considering the unavoidable exposure to AlCl3 in several manufactured foods and medicines, there is a need to combat this threat through affordable natural products like herbs.
Aims: This study aimed at investigating if Salacia reticulata ameliorates aluminum chloride-induced cellular changes in the cerebral cortex of Wistar rats.
Methods: Animals were assigned into three groups: Group A control (distilled water 1 ml/kg), Group B AlCl3 65 mg/kg b.w., and Group C AlCl3 (65 mg/kg b.w.) plus Salacia reticulata (250 mg/kg b.w.), respectively. Rats were orally administered their respective doses daily for 14 days.
Results: The effect of these treatments was studied on harvested brain tissues stained using H&E and the slides obtained were mounted on a microscope. The film obtained from the slides showed cellular and neutrophil profile in Group B, which was absent in Group A on the administration of Salacia reticulate Group C a full recovery of cellular and neutrophil was observed.

Conclusion: Aqueous extract of Salacia reticulata has the potency to revert structural degeneration of cerebral cortex neuron caused by aluminum chloride.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.29333/ejmets/11884

ELECTR J MED ED TE, 2022 - Volume 15 Issue 2, Article No: em2205

Publication date: 08 Mar 2022

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Article Downloads: 64

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